Abstract
Conclusion and summary
The data indicate that on mixing tissue pulp from the lungs of freshly killed adult rats with blood serum or fraction of blood serum containing proplasmin, fibrinolytic activity appeared in the mixture. This was presumably due to activation proplasmin of serum by a tissue kinase present in the lung tissue. The kinase activity was found to be concentrated in the microsome fraction of the tissue, while the inhibitory activity was in the supernate. The system described here may be identical with that proposed by Astrup and Permin. 7 It is known also that the microsome fraction of lung tissue contains most of the thromboplastic activity of the total tissue extract, 5 although this should not be construed as indicating an identity between the kinase and thromboplastin.
Get full access to this article
View all access options for this article.