Abstract
Summary
The beta cells of the rat's pancreas can be completely degranulated within 15 minutes by a single intra-cardiac injection of glucose. Dosage: 3.0 g glucose per kilo body weight.
The phenomenon of degranulation is reversible; regranulation follows degranulation, but requires about 48 hours.
Rats with degranulated beta cells show a reduced glucose tolerance, elevated fasting blood sugars, and glycosuria.
The addition of 3 units of crystalline zinc insulin per 1.0 g of glucose does not prevent the degranulation of the beta cells due to a delay in the effect of the injected insulin and the consequent production of a hyperglycemia.
Repeated injections of glucose cause a functional impairment of the beta cells as evidenced by the production of a temporary diabetic state.
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