Abstract
Summary
A mouse protection test in which penicillin products are used prophylactically against subsequent challenge with Pneumococcus Type I is described. This test was used to evaluate repository type dosage forms of the antibiotic agent for their ability to prolong a period of protection against infection. Of the preparations tested the nonrepository aqueous solution of sodium penicillin was least effective, tlhe suspensions of procaine penicillin in water or in oil were approximately equal in their activity, large particle size sodium penicillin in beeswax and oil was more effective, and small particle procaine penicillin suspended in oil and aluminum monostearate was the most effective preparation tested.
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