Abstract
Summary
(1) Rats ovariectomized at weaning were maintained on a vitamin E-de-ficient diet for from 6 weeks to 10 months. No difference in the uterine weight response to injected estradiol benzoate was discernible between these animals and control animals of the same age maintained on the same diet supplemented by alpha-tocopherol acetate
(2) The uterine weight response to alphaestradiol benzoate was significantly greater at 3 months of age than at 10 months regardless of tocopherol administration.
(3) Accumulation of acid-fast pigment in the uterus is characteristic of intact rats maintained on a vitamin E-deficient diet. Ovariectomy at weaning prevented the appearance of uterine pigmentation in animals maintained on the deficient diet for as long as 10 months.
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