Abstract
Summary
Upon the basis of the data presented, it is concluded that desoxypyridoxine exerts its inhibiting effect by being first converted into desoxypyridoxine phosphate which then competes with pyridoxal phosphate for the apoenzyme. This conclusion offers an explanation for the observation that in the animal, desoxypyridoxine exerts its antagonistic effect primarily under conditions of restricted vitamin B6 intake.
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