Abstract
Summary
Methyl-bis (beta-chloroethyl) amine hydrochloride has been demonstrated to exert effective virucidal and bactericidal effects in the presence of either plasma, serum or whole blood. The required virucidal dosage of HN2 is below 500 mg/l of blood or plasma if the pH is at or near 7.0. The end products of decomposition of the added HN2 are essentially nontoxic if the pH of the system is not too low. No evidence of antigenic or other toxic reactions has been produced in two dogs and two humans receiving repeated injections of treated plasma. Human red blood cells withstand the application of virucidal dosages of HN2 without hemolysis and with only a slight increase in fragility. Complement, immune bodies, phosphatase and fibrinogen are only slightly affected by sterilizing dosages of HN2. Prothrombin time is markedly prolonged by HN2.
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