Relation of Fat and Protein Intake to Fatty Changes,Fibrosis and Necrosis of the Liver. *

Abstract

Summary

1. Groups of rats were fed diets of 16% protein and 51% fat; 6% protein and 6% fat; and 4% protein and 6% fat. These diets resulted in a fatty infiltration of the liver, and in the long term experiments this was accompanied by a diffuse, progressive, hepatic fibrosis.

2. The hepatic lesions produced by all 3 of these diets appeared to be the same type and probably had the same basic pathogenesis.

3. Hepatic necrosis was not produced by the diets used, and deaths from acute hepatic necrosis were not obtained with a low protein intake.