Condensation of 2,3-Dimercaptopropanol (BAL) with Oxophenarsine Hydrochloride: Toxicity and Chemotherapeutic Effect

Abstract

Summary

1. The condensation product of BAL and oxophenarsine hydrochloride (BAL-OXO) was studied. Its toxicity in mice and chemotherapeutic activity in T. equiperdum is reported, in comparison with similar data, for oxophenarsine hydrochloride.

2. The acute toxicity of the thioarsenite, BAL-OXO is approximately 1/4 that of the arsenoxide (oxophenarsine hydrochloride) from which it was prepared.

3. The BAL-OXO has less therapeutic advantage, i.e., lower LD₅₀/CD₅₀, in mouse trypanosomiasis than oxophenarsine hydrochloride itself.