Abstract
Discussion and summary
Data are presented on the effect of various antibacterial agents on a representative group of organisms associated with cases of chronic and acute mastitis.
Subtilin was effective in high dilution against the gram positive organisms. Streptomycin appeared to more active against the gram positive cultures than against the gram negative organisms. Strain variations among cultures of the same species of organism may have been responsible for the poor action of streptomycin against these particular gram negative organisms.
The strains of S. aureus and S. typhimurium were resistant to the sulfonamides employed. Str. agalactiae and C. pyogenes were susceptible to sulfapyridine, sulfone, sulfadiazine and sulfamerazine. In vivo study is necessary to prove these drugs of value as adjuncts to penicillin in the treatment of chronic streptococcic mastitis and so-called “summer mastitis.” E. coli was sensitive to sulfapyridine, sulfamethazine, sulfadiazine, and sulfamerazine among which sulfamerazine and sulfamethazine showed great activity. Br. abortus was susceptible to sulfamethazine, sulfadiazine, and sulfamerazine. Ps. aeruginosa was inhibited by sulfamerazine and sulfapyridine. Against the strain of Ps. aeruginosa employed, sulfadiazine was the most effective antibacterial agent.
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