Abstract
Summary
Investigation of the origin of irregular titration results has led to the Observation that soaps and synthetic ionic detergents exert a great effect on the character of inhibition titrations involving purified, formolized swine influenza virus (vaccine) and the egg-white (EW) inhibitor of vaccine hemagglutination. The amount of detergent needed for such an effect is of the order of the amount which is sufficient to cover the internal glass surface of a titration tube with a single, close-packed uniniolecular layer. While the detergent effect shows a dependence on detergent concentration, there exists a broad range of detergent concentrations over which the effect on the inhibition is essentially constant. For reasons indicated, the effect of detergent has been provisionally interpreted as an effect on the interaction of EW inhibitor and vaccine.
The mechanism of the detergent effect is being investigated and will be the subject of a subsequent report.
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