Abstract
Summary
Six quinoline derivatives have been administered intravenously and subcutaneously to rabbits and rats. There was no functional or anatomical evidence of damage to the islands of Langerhans or to any other organ under the conditions employed.
A seventh compound, N- 2-(p-Diethylaminostyryl)-6-methyl quinoline-ethochloride caused lesions of the islands resembling the early necrosis produced by alloxan. The lesions occurred in 8 of 28 animals tested. Islet necrosis was always associated with lethal dosage but death from the drug was not always accompanied by necrosis. Tubular damage in the kidney was found in all cases examined. Survival with diabetes was not observed.
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