Relation of Iodinated β-amylose (Tridine) to Some Thyroid Functions.

Abstract

Summary

1. Iodinated β-amylose, tridine, prevents partially the thyroid hyperplasia caused by thiouracil. In this respect it acts like potassium iodide. Triane, except in toxic concentrations has no effect on the meta-bolic rate.

2. In rats receiving thyroxin, tridine, in dosages of 1, 3 and 5% of the diet, has no significant effect on either the size of the organs or the metabolic rate.

3. In young rats all dosages of tridine (1, 3 and 5%) are deleterious with respect to consumption of food and gain in body weight.

4. In thiouracil-treated rats 3% tridine is indistinguishable in its effects from an- equivalent (0.77%) amount of KI.

5. The data from the present series of experiments on 78 rats suggest that tridine when administered by mouth exerts its effect by virtue of its iodine content and when given in equivalent amounts cannot be distinguished from KI.