Effect of Dibenamine on Renal Function. *

Abstract

Summary

1. Six weekly intravenous injections of Dibenamine (20 mg/kg) failed to produce any detectable renal damage as measured by creatinine and PAH clearances in 5 trained, unanesthetized female dogs, even when the entire dose was injected within one minute so as to produce maximum toxic side-effects including prostration for 24 to 48 hours.

2. During maximal sympathetic blockade by Dibenamine, renal plasma flow was reduced, 10 to 34% (average 21%), probably on the basis of reduced systemic arterial pressure. However, the filtration fraction was sufficiently elevated to provide unaltered glomerular filtration. These alterations never persisted beyond the period of active adrenergic blockade.

3. We have been completely unable to substantiate the observations of Ogden⁷ on the renal toxicity of Dibenamine or to find any renal bask for his warning regarding its use. Even large doses of Dibenamine administered very rapidly appear to have no significant reno-toxic action.