Abstract
The following is a brief summary of our results:
Comparing the Action of Vaughan's Egg-white Poison to Unbroken Protein.
1. Inoculations of the unneutralized acid poison into normal guinea pigs gave the same picture as that of the unbroken protein when inoculated into sensitized guinea pigs, whether the poison was given intraperitoneally or intracerebrally. The filtrate from the neutralized poison injected intracardiacally also gave typical symptoms.
2. Effect of Heat. — The egg-white poison was not affected when heated to 100° C. for 15 minutes; heated to 120° C. for 15 minutes it was reduced, but its toxic action not completely destroyed.
3. Chloral Hydrate. — Normal guinea pigs under the influence of chloral were completely protected against one and a quarter fatal doses of the poison. If two or more fatal doses are given death results. Chloral mixed with the poison, and then given, caused irregular results which was interpreted as meaning that there is no chemical union of the chloral and poison in vitro. We assume that the chloral protects by union with certain vital cells.
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