Abstract
By employing as a virus the spinal cord from two human cases of epidemic poliomyelitis, it has been found possible not only to transmit the disease to monkeys, as Landsteiner and Popper 1 did, but by employing the intracerebral mode of inoculation, to propagate the disease successfully through a long series of monkeys. In this manner, epidemic poliomyelitis or infantile paralysis has been opened up to experimental study.
It has been proven conclusively that the symptoms and pathological lesions of epidemic poliomyelitis are identical with those occurring in the spontaneous disease of man. It has next been shown that the virus of poliomyelitis is effective in monkeys not only when introduced into the brain, but also when injected into a large nerve (sciatic nerve), into the circulation, into the peritoneal cavity, and beneath the skin.
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