Mucolytic Enzyme Systems. IV. Relationship of Hyaluronidase Inhibition by Blood Serum to Incidence of Mammary Cancer in Mice. ∗

Abstract

Summary

1. Within the A, Z, and AZF ₁ strains of mice, no significant differences in the hyaluronidase-inhibitor levels in serum were found between individuals with and without the milk agent which determines the incidence of mammary cancer. Neither was a significant difference observed between virgins and breeders of the same strain or between individuals with and without tumors. 2. There appeared to be a tendency for the inhibitor titer to vary inversely with the strain incidence of mammary cancer in the A, Z, and AZF₁ mice. 3. A tendency toward an inverse relationship between the inhibitor level and the presence of the “inherited hormonal factor” follows.