Abstract
Summary
In human patients receiving dicumarol the plasma Ac-globulin level may be depressed by 20-50% following initiation of therapy. Individual variation was noteworthy. A gradual return to normal concentrations of Ac-globulin occurs within 3 weeks as therapy is continued and the prothrombin is maintained at a low titer. No appreciable difference from normal was found in the Ac-globulin values of patients who had been on dicumarol therapy for 1 to 14 months.
Dogs receiving larger dicumarol doses than were administered to human patients showed a similar Ac-globulin response and a more marked reduction in prothrombin. A period of slightly lowered Ac-globulin activity in the dog is followed by a temporary rise to levels above normal.
Get full access to this article
View all access options for this article.