Abstract
Conclusions
Necrosin is a substance associated with the euglobulin fraction of usually acid inflammatory exudates. Its liberation by injured cells offers a reasonable explanation for the basic pattern of injury in inflammation.
The subcutaneous injections of canine necrosin, at a distance from the site of spontaneous tumors, in a strain of Swiss mice produce, after varying intervals, hemorrhagic or other types of necrosis in the tumor substance.
A necrotizing effect is also seen to occur in some of the metastatic lesions encountered in the lung.
Necrosin injections in these mice induce severe injury to the liver.
None of the effects on the tumor or on its metastasis are usually encountered with the use of the euglobulin fraction of canine blood serum, the leukocytosis-promoting fraction of canine exudates, or with one of the proteolytic enzymes adequately studied, namely papain.
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