Comparison of Penicillin G and A Biosynthetic Penicillin With Regard to Diffusion into Cerebrospinal Fluid

Abstract

Summary

BT penicillin (n-butylthiomethyl penicillin) gave no evidences of toxicity, either immediate or delayed, following the intravenous injection of 500,000 units in 11 patients. From the work here reported it appears that BT penicillin does not diffuse into the cerebrospinal fluid as readily as benzyl penicillin and plasma concentrations resulting from its use are essentially the same as those following the use of benzyl penicillin.