Abstract
Summary
Crude and purified cephalin and antithromboplastin extracted from brain tissue yield characteristic activity curves when tested at different concentrations, on stable citrated normal human plasma. Moderate dilution accelerates the coagulation of normal and hemophilic blood and plasma and delays that of posthemorrhagic blood and plasma. Excepting fraction V, all Cohn's plasma fractions have coagulant action; only fractions IV-1 and IV-4 display a triphasic curve of activity, an indication that they are mixtures of coagulants and anticoagulants.
Get full access to this article
View all access options for this article.