Abstract
Summary
Adrenalin injected intraperitoneally causes neutrophilia and a marked lymphopenia in rats in doses varying from 0.5 to 1 γ100 g. This effect is absent in adrenalectomized animals and it is greatly diminished in normal rats injected with large quantities of adrenocortical extracts. It is suggested in agreement with Sayers and Sayers that adrenalin increases the consumption of adrenocortical hormones in the tissues and that the lowering of their concentration in the blood leads to increased secretion of the adrenotrophic hormone which in turn increases secretion of adrenocortical hormones. The latter induce lymphopenia.
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