Abstract
Summary
There was no marked difference in the distribution of the acid-soluble phosphorylated intermediates of glycolysis in the heart muscle of normal and digitoxinpoisoned rats. Small differences in the glycogen values of heart values were noted, but there was an increased amount of liver glycogen in the digitalized animals as compared with the controls as indicated by an average of 2.39% of glycogen in the former and 1.85% in the liver of the latter. Neither was there any difference in the rate of breakdown of glycogen in the excised liver tissue in normal and digitoxin treated rats. Increased glycogenesis occurred in the liver of rats given nontoxic doses of digitoxin while toxic doses of the drug resulted in a decrease in the amount of liver glycogen in rats in which symptoms of over-digitalization were manifested.
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