Excretion of Androgens and 17-Ketosteroids in the Cebus Monkey Following the Administration of Testosterone Propionate

Abstract

Discussion and Summary

As previously stated, the administration of testosterone to many animals including man and the Rhesus monkey, results in an increased urinary excretion of androgens and 17-ketosteroids. In contradistinction to this we noted no increase in either of these substances in the urine of treated Cebus monkeys. This finding parallels those of Dingemanse and Tyslowitz 10 , Paschkis et al. 11 , who found no increase in the urine of dogs similarly treated. In dogs 11 and man 12 increased urinary estrogenic activity has been shown after testosterone treatment. Our results would suggest that in the Cebus monkey as in man and the dog, testosterone can be converted to estrogens, but further work is necessary to elucidate this point.