Abstract
Summary
1. A purified diet containing sulfathiazole produced a hemolytic anemia of variable intensity which could not be completely reversed either by pteroylglutamic acid or by xanthopterin in any of the doses used.
2. Rats fed a purified diet containing succinylsulfathiazole developed leukopenia and an inhibition of growth which responded to PGA, but not to xanthopterin.
3. In similar rats fed a purified diet containing succinylsulfathiazole, but made anemic by repeated hemorrhage, PGA induced definite erythropoietic, leukopoietic and growth responses, while xanthopterin was inactive.
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