Influence of Protein Reserves on Nephrectomized and Renal Artery Ligated Dogs. ∗

Abstract

Summary and Conclusions

Renal artery ligation as well as nephrectomy was carried out in 2 groups of dogs, one maintained prior to the operation on a carbohydrate, the other on a protein diet. Following either operative procedure the nitrogen catabolism was more rapid, the toxic symptoms more severe, and the survival time shorter in protein pre-fed animals as compared with the carbohydrate group. In the former the contrasting results of renal artery ligation and nephrectomy are marked. It may be concluded both that substances derived from the ischemic kidney stimulate catabolism of protein reserves and that the toxic symptoms following renal artery ligation are associated with accelerated nitrogen catabolism.