Abstract
Summary and conclusions
1. The phenomenon of tachyphylaxis of the intestinal musculature to morphine was demonstrated.
2. The most consistent reponse of the circular muscle of the duodenum to morphine was an increase in the many phases of muscular activity. This includes elevation of the tonus level with incerased frequency and amplitude of the normal spontaneous tonic contractions.
3. The most frequent though not completely consistent reponse of the lingitudinal muscle was found to be either a decrease or an abolition of the many phases of the muscle activity. This includes a depression of the tonus level with a decreased frequency and amplitude of the normal spontaneous tonic contractions.
4. The type of response of the duodenum to morphine was independent of the original state of tonus and independent of the dose over the range of 0.01 mg to 1.0 mg per kg.
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