Abstract
Summary
A number of synthetic nucleosides, and chloro- and bromo- derivatives of these nucleosides, were tested for growth-promoting and growth-inhibiting properties on Escherichia coli, strain 9723, and its uracil-re-quiring mutant, E. coli, strain 550-460; Neuro-spora crassa, wild strain Abbott 4A, and a uracil-less strain of Neurospora crassa, No. 1298; and on the growth of Lactobacillus casei and Streptococcus faecalis R.
The compounds tested were the 1-D-ribosyl-, 1-D-arabinosyl-, 1-D-glucosyl-, and 1-D-galactosyl- nucleosides of uracil, thymine, 5-chlorouracil and of 5-bromouracil. Of these 16 compounds, only a few at high concentrations showed inhibitory properties on the growth of the microorganisms tested. Some showed slight, but insignificant, growth-stimulatory activity.
The authors wish to show their appreciation to Miss Ann Coblenz, Miss Janet Tozer, Miss Evelyn Wyatt, and Mrs. Charmion McMillan for carrying out some of the microbiological tests.
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