Abstract
Summary
Two cases are described in which type N individuals produced anti-M agglutinins following injections at widely spaced intervals of blood containing the M agglutinogen. On the basis of these and other observations, it is pointed out that type N patients requiring a series of transfusions at wide intervals should be transfused only with type N blood, if isosensitization and consequent transfusion reactions are to be avoided. Genetic and serologic analogies among the A-B-O, M-N and Rh-Hr systems of blood factors are pointed out. Evidence is cited to show that the factors in each system fall naturally into two major subdivisions.
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