Abstract
Summary
The effect of the disodium salt of dicumarol was observed on 14 day embryonic chick liver and spleen cultured in a 10% rabbit serum and Tyrode solution. Concentrations of dicumarol of 1/100,000 and 1/50,000 did not appear to inhibit the proliferation of endothelial cells at 48 and 72 hours when compared with control cultures. However, with a concentration of 1/10,000 cellular proliferation was present at 48 hours, but at 72 hours these cells had been killed and lysed. In contrast, spleen cultures of 14 day chick embryos showed cellular proliferation in media containing dicumarol in concentrations of 1/50,000 and 1/10,000 at both 48 and 72 hours.
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