Abstract
Summary
A new use of the rabbit ear chamber technic is described.
Microscopic studies of the tissue changes in developing tuberculous infection within the chamber were made. The early reaction to the presence of living tubercle bacilli was minimal. The late reaction was an explosive, necrotizing response. In the one rabbit systematically skin tested with Old Tuberculin this late reaction began coincidentally with the development of skin hypersensitivity. Progressive vascular damage ending in venous thrombosis played an important role in tissue destruction.
The experimental technic and microscopic observations described have been recorded in Kodachrome motion pictures. It is suggested that this technic may be used for microscopic study of the dynamics of tissue changes in other pathological conditions.
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