Value of Soybean Trypsin Inhibitor in Preventing the Toxic Effects of Human Placental Thromboplastin. ∗

Abstract

Conclusion

1. When given intravenously to 4 species, the soybean trypsin inhibitor, in doses up to 0.5 g/kg, was devoid of any apparent toxic or anaphylactic effect. In the monkey, it was noted that the material caused a prolongation of the plasma coagulation time.

2. Given either intravenously or intramuscularly, the soybean trypsin inhibitor offered considerable protection against the subsequent administration of lethal doses of human placental thromboplastin, as shown in Table I.