On the Antitumorigenic Action of Large Quantities of Pregnenolones

Abstract

Summary

With quantities of 3-acetate-pregnenolone about 30 to 50 times those of the antifibromatogenic minimum of progesterone, estrogen-induced abdominal fibroids can be prevented in the guinea pig to a very considerable degree. This is the first statement of an antifibromatogenic activity of a steroid with an hydroxyl group at C_3. There was only a slight diminution of the fibromatogenic effect when quantities of 21-acetoxy-pregnenolone as large as 50 to 80 times those of progesterone were given.