Abstract
Summary and Conclusion
From the data it can be seen that rutin inhibits the spread of intradermally injected india ink to which hyaluronidase or saline is added. The effect is statistically highly significant. From the analysis of variance it is evident that the results are due to rutin treatment and not variations within the individual animals. Propylene glycol, which was used as the rutin solvent, inhibits the spreading power of hyaluronidase and this inhibition is increased by a highly significant factor when rutin is also present. Propylene glycol produces slight shock and the resultant liberation of adrenalin probably is responsible for inhibition of hyaluronidase activity. Favilli 10 and Homburger 11 have shown that adrenalin has this property.
Rutin markedly inhibits the ipreading activity of intradermally injected inlied hyaluronidase. The spread of control injection of ink is also inhibited. Propylene glycol exerts a similar but less intense effect on hyaluronidase and does not reduce the spread of control injections ol ink.
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