Abstract
Summary and Conclusions
1. Drug 194 (N-benzyl-N-β-phenylisopropyl-β chloroethylamine hydrochloride), has been shown to be a potent antagonist of certain excitatory effects of a number of sympathomimetic agents. In the cat, 194 reduced or abolished pressor responses to aliphatic and aromatic amines and to catechol. In the presence of 194, all the compounds, except neosynephrine, privine, and paredrinol, manifested depressor activity.
2. The effects of nerve stimulation on the nictitating membrane of the cat were less effectively blocked by 194 than were the effects of epinephrine. 194 also could prevent or interrupt nictitating membrane contractions induced by sympathomimetic amines other than epinephrine.
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