Abstract
Summary
1. Tween 20 produces urticaria and stimulates gastric secretion when injected intravenously in a dose of 0.8 mg/kg in dogs with gastric pouches.
2. Pretreatment with benadryl (10 mg/kg intravenously) prevents or reduces the urticariogenic and secretory effects of Tween 20 in most instances.
3. Inasmuch as benadryl does not inhibit histamine-stimulated gastric secretion, the mode of action of benadryl in counteracting Tween 20 stimulated secretion must involve another mechanism.
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