Abstract
Summary
The amount and distribution of cytoplasmic ribonucleic acid, alkaline phosphatase and mucin was studied in the vaginal epithelium of ovariectomized mice and in castrates injected with estrogen and progesterone. In the untreated castrate the vaginal epithelium contains negligible quantities of all these cellular constituents. Injection of estrogen, and estrogen with progesterone concurrently, results in a marked increase in both phosphatase and ribonucleic acid. Mucification occurs only when the two hormones act simultaneously. Progesterone alone has no effect on any of the substances studied.
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