Abstract
Summary
Chronic administration of sulfamethazine to normal male rats causes gross and microscopic atrophic changes in the testes, seminal vesicles and anterior prostate but a hyperplasia of the thyroid gland. The reported hypertrophy of the accessory organs 1 of the young male rats treated with sulfamethazine was not confirmed. When hypophysectomized rats were fed with sulfamethazine, only increased atrophy of the testes was manifested. The atrophic changes that occurred in the testes and accessory organs in normal rats, as well as the similar changes in the testes of the hypophysectomized male rats after chronic administration of sulfamethazine, are attributed to a direct effect of the drug on the testes.
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