Abstract
Summary
Recovery curves of conductivity of the A-V node and ventricles for the isolated rabbit heart driven at various rates followed the usual logarithmic pattern. Strophanthin, and especially quinidine, caused delayed recovery and more prolonged refractoriness of both regions of the heart. Strophanthin prolonged the Q-T interval in small doses and usually shortened it in larger doses. Quinidine effects upon the Q-T interval were unexpectedly variable, contrary to the usual prolongation in thyrotron driven ventricles and in clinical cases.
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