Phospholipid Utilization in the Diabetic Dog. ∗

Abstract

Summary and Conclusions

Phospholipid tagged with radioactive phosphorus- was injected intravenously into normal and diabetic dogs. From the rate of disappearance of the tagged phospholipid from the blood stream and the plasma lipid phosphorus level, the rate of utilization of phospholipid was calculated. It was observed in both normal and diabetic groups that the rate of utilization was roughly proportional to the plasma lipid phosphorus concentration. The absolute utilization of plasma phospholipid was slightly lower in the diabetic group, but the proportion of plasma phospholipid utilized per hour was significantly higher in this group. Administration of insulin and sugar to diabetic dogs caused no significant change. Administration of raw pancreas to diabetic dogs increased the absolute utilization very markedly and the proportion utilized per hour only slightly.