Abstract
Summary
Injection of emetine into rabbits was followed by a relatively high drug concentration in the liver for more than a month, whereas the level in the intestine was always much lower and became undetectable after 4 days. The findings of a high concentration and prolonged presence of emetine in the liver and a low concentration and transient presence of the drug in the intestine are proposed as the explanation for the efficacy of emetine in amebic liver disease and the drug's failure in amebic intestinal disease in man.
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