Distribution and Rate of Disposition of Myanesin in Dogs

Abstract

Summary

1. From a study of plasma concentrations of animals infused continuously, it has been shown that dogs can dispose of between 1 and 2 mg of myanesin per kg per minute, irrespective of plasma concentration between the limits of 50 and 130 μg per ml. 2. The rapid disposition of myanesin is due primarily to metabolic alteration. 3. Myanesin is widely distributed in the body approximately according to water content. A notable exception to this is found in the brain where tissue/plasma ratios of greater than 2 are observed.