Abstract
Summary
1. Penicillin and streptomycin were found in the lungs of rats in far greater concentrations following inhalational administration than after intramuscular injection of similar and even higher doses,
2. Penicillin was retained in the lungs in a high concentration for 1 hour following inhalation. It was still detectable in smaller amounts at 2 hours.
3. Streptomycin was retained in the lungs in an effective concentration for at least 3 hours following inhalation.
4. Penicillin was present in the blood stream in effective concentrations for 2 hours following inhalation.
5. Streptomycin was poorly absorbed from the lungs into the blood following inhalation.
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