Abstract
Conclusions
1. Strains of highly mouse virulent poliomyelitis virus as transmitted in mice or in embryonated eggs may be transmitted to rats without symptoms but with the development of virus of high titer in the brain in the first passage.
2. Such rat brain virus may be used to immunize rabbits effectively, and the antiserum so obtained neutralizes homologous and heterologous strains of the “high” variety, namely MM, high SK, and high Lansing.
3. The above antiserum does not neutralize the well known “low” Lansing strain of poliomyelitis virus.
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