Abstract
Summary
The daily injection of DCA, in 5 patients with uncomplicated hypertensive vascular disease for periods of 30 days or more, produced a transitory rise in “resting” blood pressure in all instances, a sustained increase during the period of drug administration in but 3 of the 5 subjects.
The continued injection of DCA was associated with a progressive drop in serum potassium concentration, an increase in carbon dioxide content and a fall in chloride concentration. Salt and water retention, on the other hand, was observed only during the first 7-10 days of treatment, with reversal to control levels thereafter.
The pressor action of DCA does not appear to be due to a direct humoral mechanism dependent on its concentration in the circulation.
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