Abstract
Conclusions
The sum total of the work reported leads to the conclusion that MM virus, inactivated by exposure to various physical and chemical agencies, is unable, as a rule, to prevent the development of paralysis in monkeys infected with simian virus under the conditions employed in these tests. The slight and irregular protection observed on occasion with the use of chlorinated murine virus is exceptional and operates only against limited doses of simian virus. The results are, therefore, in marked contrast with the high rate of non-paralytic survival that is obtainable when unmodified active virus is used as interfering agent in comparable amounts. While interference with active murine virus still offers the only successful approach—known at present—to a prevention of the experimental disease, the fact that inactivation of the virus causes a definite qualitative or quantitative alteration of the effective interfering factor opposes serious difficulties to a possible application of this method for human use.
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