Chloromycetin in the Treatment of Patients with Typhus Fever

Abstract

Conclusion

On the basis of these limited observations, it may be concluded that the administration of Chloromycetin to patients with typhus fever is a relatively safe procedure. Furthermore, the chemotherapeutic effect obtained in the few patients treated was sufficiently encouraging to warrant further tests with the drug. It is suggested that Chloromycetin be employed in oral treatment of the next group of patients to be studied according to the following schedule; an initial dose of 40 mg per kilo body weight followed by a total daily dose of 35 mg per kilo body weight, given in divided amounts at 2-hour intervals, until obvious improvement in the patient's condition is noted; subsequently maintenance dose of 20 mg per kilo body weight per day given in divided amounts at 4-hour intervals, until the 13 th or 14th day after onset.