Abstract
Summary
(1) The effects of single and repeated convulsions induced by electroshock were observed in 6 chronic decorticated cats. (2) The seizures were characterized by a posture of general semiflexion with small amplitude rapid rhythmic movements of the limbs, jaws and facial musculature, interrupted by one or more short quiescent periods, terminating in running movements after which a more prolonged quiescent phase preceded recovery. Apnea occurred during the seizures and was followed by transitory hyperpnea. (3) Body temperature and pulse rate were not affected significantly. Righting reflexes returned a few minutes after each seizure. Licking reflexes were abolished for from 1 to 3 1/2 hours after each convulsion in 3 preparations. Sham rage in response to a non-nociceptive stimulus was unaffected or enhanced temporarily after each electroshock convulsion. Sham rage responses (chiefly facio-vocal) to nociceptive pressure stimuli applied to the tail were markedly reduced or abolished for from 1 to 2% hours after each electrically induced seizure. (4) No changes other than those noted after single electroshocks were noted after repeated electrically induced convulsions. (5) The electro-encephalographic patterns of electroshock convulsions in the decorticated preparations were characterized by bursts of relatively high voltage 2 to 21 per second rhythms separated by short silent intervals, frequently terminating in a steady 15 to 18 per second discharge before cessation of electrical activity. Slow and fast wave sequences appeared at times during the paroxysmal discharges and were more prominent in previously morphinized preparations. (6) Gross and microscopic studies of the remaining brains after completion of the experiments revealed no changes which could be ascribed to the electric currents used to evoke convulsions.
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