Abstract
Summary
A controlled study was made of side reactions to pyribenzamine. Five 50-mg tablets were given over a 24-hour period to 48 subjects; some subjects were used 2 or 3 times, and the total number of times the drug was given was 100. Placebos were given to 49 subjects a total of 102 times. The dosage of pyribenzamine was doubled in 37 other subjects on 56 occasions. Nervousness, dryness of the mouth, and headache were more frequent in the control group as compared with the smaller dose group of pyribenzamine. Drowsiness, nausea, dizziness and insomnia were less frequent in the control group. All side reactions mentioned occurred more frequently when the dose of pyribenzamine was doubled.
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