Abstract
Conclusions
1. The totally isolated stomach with intact blood and nerve supply secretes large amounts of gastric juice even in the absence of food-taking.
2. On the ingestion of food there occurs an immediate augmentation of secretion followed by a period of inhibition lasting 3 to 7 hours and then a period of profuse secretion.
3. Section of the vagus nerves above the diaphragm reduces the secretion of gastric juice in the isolated stomach by an average of 56% and the output of hydrochloric acid by 77%. Nervous factors are thus more important than other mechanisms in determining gastric secretion in these animals.
4. Chronic progressive peptic ulcers occur frequently in these isolated stomachs and cause death by hemorrhage or perforation. They rarely develop in such preparations that have been denervated, and following vagotomy, they tend to heal.
5. Partial vagotomy has little or no effect on gastric secretion.
6. After complete vagotomy, the secretory response to a standard dose of histamine is markedly reduced.
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