Hepatic Fibrosis in the Persistently Non-Fatty Liver of the Hypophysectomized Dog

Abstract

Summary

1. Fibrous-tissue proliferation is shown to occur in the livers of hypophysectomized dogs. Its development was not preceded by an increase in the fat content of the liver.

2. Hypothalamic damage as a cause of the fibrous-tissue proliferation was ruled out.

3. The development of hepatic fibrosis in these dogs fed a diet adequate in all respects and rich in proteins suggests that hypophysectomy induces either (a) a derangement in digestion and/or absorption, or (b) an increased need for certain dietary substances essential for the maintenance of a normal liver.